LJ-182M: UV Resistant Organism Liberty’s scientists have recently completed optimization of a novel isolate obtained from a national governmental space exploration agency. The isolate mutated in space on the exterior of an Earth orbiting satellite, developing significant resistance to chronic UVC exposure.
The X-Lab spent the last year developing the species to enhance these UVC characteristics while also baselining its efficacy in absorbing UVB and UVA, the bands of greater health concern here on Earth, as they cause skin damage and cancer. Internal testing of LJ-182M has shown similar efficacy at shielding against UVA and UVB radiation to that of leading commercial brands of SPF 50 sunscreen.
Impact With the sunscreen manufacturing and cosmetics industry having to change their formulas due to new FDA guidelines relating to the use of chemicals in sunscreens, and as more governments ban the sale/use of sunscreens due to environmental damage, there is need for a safe, biological alternative in the form of LJ-182M.
LJ-184M viewed under a phase contrast microscopy
LP-888 Efflux Pump Inhibitor This isolate produces a substance that inhibits the detrimental function of efflux pumps in human cells. The efflux pump mechanism allows bacteria to move antibiotics out of human cells and is a fundamental driver of antibiotic resistance. An inhibition of this efflux pump function could enhance antibiotic efficacy, an especially important clinical and business objective given the rapid increase in antibiotic tolerance and resistance by pathogens worldwide.
Impact The compound produced by LP-888 has been shown to reverse antibiotic resistance in a range of human pathogens, to include Methicillin-resistant Staphylococcus aureus (MRSA). Preclinical testing of LP-888 is projected to be concluded in 2020.
LP-444 Biopolymer Produced by a novel organism discovered deep within the Earth’s crust, this isolate produces a flexible, yet strong biopolymer matrix that has been shown to resist both high temperature and pressure.
Impact The biopolymer can withstand up to 450 degrees Fahrenheit, opening the door for it to lead an entirely new class of lightweight biological materials that can be used by both government and industry to solve some of the most challenging engineering and materials science problems.